• CON LA SCUSA DELLA DERMATITE NODULARE STANNO VACCINANDO E ABBATTENDO MIGLIAIA DI ANIMALI SANISSIMI!
    Una criminale legge europea impone la vaccinazione e l'abbattimento delle vacche che manifestano la Dermatite Nodulare Contagiosa (Lumpy Skin Disease, o LSD), causata - dicono gli esperti - da un fuffa-virus.
    Ma i vaccini "a virus vivo attenuato" possono statisticamente causare ogni tot capi gli stessi sintomi dell'infezione in alcuni esemplari di animali e qualora venga confermato un solo focolaio (una sola mucca), i protocolli sanitari prevedono l'abbattimento dell'intera unità epidemiologica per prevenire la diffusione del contagio.
    Quindi li abbattono TUTTI indistintamente.
    Avete capito spero che lo scopo non è sanitario ma è quello di distruggere la produzione italiana (e non solo italiana) di carne, per lasciare posto a quella di altri paesi inoculata con sieri pericolosi, o peggio ancora, alla carne sintetica di Bill Gates...
    Ma noi, che abbiamo imparato a concepire le peggiori cose sui criminali governanti nostrani, pensiamo anche che ogni tot animali trattati col normale vaccino a virus attenuato, si inoculino di proposito, vigliaccamente, ad alcuni capi scelti il virus non attenuato allo scopo di provocare la malattia e avere il pretesto di abbattere l’intera mandria!
    Diabolico e terrificante, ma molto realistico!
    Svegliaaaaaaaa…..

    PS: cosa aspetti, unisciti a Disinformazione.it

    NDR.: testo parzialmente modificato, nonché completato col pensiero finale da “Cervelli pensanti”.
    CON LA SCUSA DELLA DERMATITE NODULARE STANNO VACCINANDO E ABBATTENDO MIGLIAIA DI ANIMALI SANISSIMI! Una criminale legge europea impone la vaccinazione e l'abbattimento delle vacche che manifestano la Dermatite Nodulare Contagiosa (Lumpy Skin Disease, o LSD), causata - dicono gli esperti - da un fuffa-virus. Ma i vaccini "a virus vivo attenuato" possono statisticamente causare ogni tot capi gli stessi sintomi dell'infezione in alcuni esemplari di animali e qualora venga confermato un solo focolaio (una sola mucca), i protocolli sanitari prevedono l'abbattimento dell'intera unità epidemiologica per prevenire la diffusione del contagio. Quindi li abbattono TUTTI indistintamente. Avete capito spero che lo scopo non è sanitario ma è quello di distruggere la produzione italiana (e non solo italiana) di carne, per lasciare posto a quella di altri paesi inoculata con sieri pericolosi, o peggio ancora, alla carne sintetica di Bill Gates... Ma noi, che abbiamo imparato a concepire le peggiori cose sui criminali governanti nostrani, pensiamo anche che ogni tot animali trattati col normale vaccino a virus attenuato, si inoculino di proposito, vigliaccamente, ad alcuni capi scelti il virus non attenuato allo scopo di provocare la malattia e avere il pretesto di abbattere l’intera mandria! Diabolico e terrificante, ma molto realistico! Svegliaaaaaaaa….. PS: cosa aspetti, unisciti a Disinformazione.it NDR.: testo parzialmente modificato, nonché completato col pensiero finale da “Cervelli pensanti”.
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  • CASO STRANO? IL VACCINO contro l'HANTAVIRUS È STATO GIÀ DEPOSITATO NEL 2022???

    Certamente. Ecco il contenuto del file che hai caricato, letto e poi tradotto in italiano.

    TESTO PRESENTE NEL BREVETTO:

    Bukreyev et al.

    (19) United States
    (12) Patent Application Publication
    (54) MRNA VACCINES AGAINST HANTAVIRUS

    (71) Applicant: Board of Regents, The University of Texas System, Austin, TX (US)

    (72) Inventors: Alexander Bukreyev, Galveston, TX (US); Mariano Garcia-Blanco, Galveston, TX (US); Ivan Kuzmin, Galveston, TX (US); Ruben Soto Acosta, Galveston, TX (US)

    (21) Appl. No.: 18/691,787
    (22) PCT Filed: Sep. 15, 2022
    (86) PCT No.: PCT/US2022/043631
    § 371 (e)(1), (2) Date: Mar. 13, 2024

    Related U.S. Application Data
    (60) Provisional application No. 63/245,101, filed on Sep. 16, 2021.

    Publication Classification
    (51) Int. Cl.
    A61K 39/12 (2006.01)
    A61K 39/00 (2006.01)
    A61P 31/14 (2006.01)
    C12N 7/00 (2006.01)

    (52) U.S. Cl.
    CPC
    A61K 39/12 (2013.01);
    A61P 31/14 (2018.01);
    C12N 7/00 (2013.01);
    A61K 2039/53 (2013.01);
    A61K 2039/575 (2013.01);
    C12N 2760/12134 (2013.01)

    (10) Pub. No.: US 2025/0127870 A1
    (43) Pub. Date: Apr. 24, 2025

    ABSTRACT

    One solution to the problem of Hantavirus pathology is design, production, and administration of a nucleic acid vaccine (NAV). In certain aspects the NAV is an mRNA vaccine. Certain embodiments are directed to the use of a polyprotein, which is cleaved to produce Gn (N-terminal) and Gc (C-terminal) glycoproteins, the Gn glycoprotein, the Gc glycoprotein, or the Gn and Gc glycoproteins of hantaviruses as protective antigen(s) for development of hantavirus vaccines. The Gn/Gc protein, which is cleaved post-translationally to individual Gn and Gc proteins, can be used as an antigen for vaccines. In case of DNA and RNA-based vaccines, the complete M gene, which encodes the complete single open reading frame, which is cleaved post-translationally into the Gn and Gc proteins or individual open reading frames encoding either Gn or Gc, is used.

    Specification includes a Sequence Listing.

    ---

    Traduzione in italiano

    Bukreyev et al.

    (19) Stati Uniti
    (12) Domanda di brevetto
    (54) VACCINI A MRNA CONTRO HANTAVIRUS

    (71) Richiedente: Board of Regents, The University of Texas System, Austin, TX (USA)

    (72) Inventori: Alexander Bukreyev, Galveston, TX (USA); Mariano Garcia-Blanco, Galveston, TX (USA); Ivan Kuzmin, Galveston, TX (USA); Ruben Soto Acosta, Galveston, TX (USA)

    (21) Numero pratica: 18/691,787
    (22) Deposito PCT: 15 settembre 2022
    (86) Numero PCT: PCT/US2022/043631
    Data di ingresso fase nazionale § 371 (e)(1), (2): 13 marzo 2024

    Dati di domanda USA correlati
    (60) Domanda provvisoria n. 63/245,101, depositata il 16 settembre 2021.

    Classificazione di pubblicazione
    (51) Classificazione internazionale (Int. Cl.)
    A61K 39/12 (2006.01)
    A61K 39/00 (2006.01)
    A61P 31/14 (2006.01)
    C12N 7/00 (2006.01)

    (52) Classificazione USA (CPC)
    A61K 39/12 (2013.01);
    A61P 31/14 (2018.01);
    C12N 7/00 (2013.01);
    A61K 2039/53 (2013.01);
    A61K 2039/575 (2013.01);
    C12N 2760/12134 (2013.01)

    (10) Numero pubblicazione: US 2025/0127870 A1
    (43) Data di pubblicazione: 24 aprile 2025

    SOMMARIO

    Una soluzione al problema della patologia da Hantavirus è la progettazione, produzione e somministrazione di un vaccino a base di acidi nucleici (NAV). In alcuni aspetti, il NAV è un vaccino a mRNA. Alcuni embodiment (realizzazioni) riguardano l'uso di una poliproteina, che viene scissa per produrre le glicoproteine Gn (N-terminale) e Gc (C-terminale), la glicoproteina Gn, la glicoproteina Gc, o le glicoproteine Gn e Gc degli hantavirus come antigene/i protettivo/i per lo sviluppo di vaccini contro l'hantavirus. La proteina Gn/Gc, che viene scissa post-traduzionalmente nelle singole proteine Gn e Gc, può essere utilizzata come antigene per i vaccini. Nel caso di vaccini basati su DNA e RNA, viene utilizzato il gene M completo, che codifica per l'unico intero open reading frame (quadro di lettura aperto), che viene scisso post-traduzionalmente nelle proteine Gn e Gc, oppure open reading frame individuali che codificano per Gn o Gc.

    La descrizione include un elenco di sequenze.
    CASO STRANO? IL VACCINO contro l'HANTAVIRUS È STATO GIÀ DEPOSITATO NEL 2022??? Certamente. Ecco il contenuto del file che hai caricato, letto e poi tradotto in italiano. TESTO PRESENTE NEL BREVETTO: Bukreyev et al. (19) United States (12) Patent Application Publication (54) MRNA VACCINES AGAINST HANTAVIRUS (71) Applicant: Board of Regents, The University of Texas System, Austin, TX (US) (72) Inventors: Alexander Bukreyev, Galveston, TX (US); Mariano Garcia-Blanco, Galveston, TX (US); Ivan Kuzmin, Galveston, TX (US); Ruben Soto Acosta, Galveston, TX (US) (21) Appl. No.: 18/691,787 (22) PCT Filed: Sep. 15, 2022 (86) PCT No.: PCT/US2022/043631 § 371 (e)(1), (2) Date: Mar. 13, 2024 Related U.S. Application Data (60) Provisional application No. 63/245,101, filed on Sep. 16, 2021. Publication Classification (51) Int. Cl. A61K 39/12 (2006.01) A61K 39/00 (2006.01) A61P 31/14 (2006.01) C12N 7/00 (2006.01) (52) U.S. Cl. CPC A61K 39/12 (2013.01); A61P 31/14 (2018.01); C12N 7/00 (2013.01); A61K 2039/53 (2013.01); A61K 2039/575 (2013.01); C12N 2760/12134 (2013.01) (10) Pub. No.: US 2025/0127870 A1 (43) Pub. Date: Apr. 24, 2025 ABSTRACT One solution to the problem of Hantavirus pathology is design, production, and administration of a nucleic acid vaccine (NAV). In certain aspects the NAV is an mRNA vaccine. Certain embodiments are directed to the use of a polyprotein, which is cleaved to produce Gn (N-terminal) and Gc (C-terminal) glycoproteins, the Gn glycoprotein, the Gc glycoprotein, or the Gn and Gc glycoproteins of hantaviruses as protective antigen(s) for development of hantavirus vaccines. The Gn/Gc protein, which is cleaved post-translationally to individual Gn and Gc proteins, can be used as an antigen for vaccines. In case of DNA and RNA-based vaccines, the complete M gene, which encodes the complete single open reading frame, which is cleaved post-translationally into the Gn and Gc proteins or individual open reading frames encoding either Gn or Gc, is used. Specification includes a Sequence Listing. --- Traduzione in italiano Bukreyev et al. (19) Stati Uniti (12) Domanda di brevetto (54) VACCINI A MRNA CONTRO HANTAVIRUS (71) Richiedente: Board of Regents, The University of Texas System, Austin, TX (USA) (72) Inventori: Alexander Bukreyev, Galveston, TX (USA); Mariano Garcia-Blanco, Galveston, TX (USA); Ivan Kuzmin, Galveston, TX (USA); Ruben Soto Acosta, Galveston, TX (USA) (21) Numero pratica: 18/691,787 (22) Deposito PCT: 15 settembre 2022 (86) Numero PCT: PCT/US2022/043631 Data di ingresso fase nazionale § 371 (e)(1), (2): 13 marzo 2024 Dati di domanda USA correlati (60) Domanda provvisoria n. 63/245,101, depositata il 16 settembre 2021. Classificazione di pubblicazione (51) Classificazione internazionale (Int. Cl.) A61K 39/12 (2006.01) A61K 39/00 (2006.01) A61P 31/14 (2006.01) C12N 7/00 (2006.01) (52) Classificazione USA (CPC) A61K 39/12 (2013.01); A61P 31/14 (2018.01); C12N 7/00 (2013.01); A61K 2039/53 (2013.01); A61K 2039/575 (2013.01); C12N 2760/12134 (2013.01) (10) Numero pubblicazione: US 2025/0127870 A1 (43) Data di pubblicazione: 24 aprile 2025 SOMMARIO Una soluzione al problema della patologia da Hantavirus è la progettazione, produzione e somministrazione di un vaccino a base di acidi nucleici (NAV). In alcuni aspetti, il NAV è un vaccino a mRNA. Alcuni embodiment (realizzazioni) riguardano l'uso di una poliproteina, che viene scissa per produrre le glicoproteine Gn (N-terminale) e Gc (C-terminale), la glicoproteina Gn, la glicoproteina Gc, o le glicoproteine Gn e Gc degli hantavirus come antigene/i protettivo/i per lo sviluppo di vaccini contro l'hantavirus. La proteina Gn/Gc, che viene scissa post-traduzionalmente nelle singole proteine Gn e Gc, può essere utilizzata come antigene per i vaccini. Nel caso di vaccini basati su DNA e RNA, viene utilizzato il gene M completo, che codifica per l'unico intero open reading frame (quadro di lettura aperto), che viene scisso post-traduzionalmente nelle proteine Gn e Gc, oppure open reading frame individuali che codificano per Gn o Gc. La descrizione include un elenco di sequenze.
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