Inverted microscopes offer several key advantages, making them the preferred choice for specific applications:

Working with Larger Samples:

Inverted microscopes excel when examining specimens in larger containers such as:

Petri dishes

Flasks  

Multi-well plates  

Tissue culture dishes  

The design allows for easy accommodation of these containers on the stage, enabling observation of cells growing within them.  

Easier Sample Manipulation:

The inverted configuration provides ample space above the sample for:

Micromanipulation techniques (e.g., microinjection, patch clamping)  

Adding reagents

Performing other experimental procedures directly on the specimen while observing it.

Observing Living Cells in Culture:

Ideal for studying the behavior of living cells:

Cell growth

Movement

Interactions

Allows for long-term observation of dynamic processes within living cells.  

Improved Accessibility:

The inverted design often provides better ergonomics for the researcher, reducing strain and improving comfort during extended observation periods.