The global mRNA synthesis raw materials market size was estimated at USD 1.67 billion in 2024 and is projected to reach USD 2.30 billion by 2030, growing at a CAGR of 5.78% from 2025 to 2030. The market growth is driven by the increasing adoption of mRNA technology in areas such as vaccine development, therapeutic manufacturing, and drug discovery.

mRNA is synthesized through the biological process of transcription, which occurs in the nucleus using a DNA nucleotide sequence as a template. The synthesis process involves multiple critical steps, including initiation, where the transcription machinery assembles; elongation, in which the RNA strand is extended; editing, to ensure accuracy and fidelity; and termination, where the newly synthesized mRNA strand is released.

mRNA synthesis plays a pivotal role in the development of novel therapeutics, including vaccines, gene therapies, and protein-based drugs, making the availability of high-quality raw materials essential for efficient production and broad application across the biotechnology and pharmaceutical industries.

Key Market Trends & Insights:

• In 2024, North America held the largest share of the global mRNA synthesis raw materials market, accounting for 36.13%. The region’s dominance is driven by advanced biotechnology infrastructure, strong pharmaceutical and biopharmaceutical sectors, high research and development (R&D) investment, and early adoption of mRNA-based technologies.

• Within North America, the U.S. market for mRNA synthesis raw materials is expected to grow significantly over the forecast period, supported by ongoing innovations in vaccine development, therapeutic research, and government initiatives promoting biotechnology and healthcare advancements.

• By type, the nucleotides segment held the highest market share of 37.06% in 2024. Nucleotides are essential building blocks for mRNA synthesis, and their prominence reflects their critical role in producing high-quality mRNA for vaccines, therapeutics, and other biotechnological applications.

• Based on application, the vaccine production segment accounted for the highest market share in 2024. This segment’s leadership is driven by the rapid growth in mRNA-based vaccines, increased adoption of immunization programs globally, and the proven efficacy of mRNA technology in preventing infectious diseases.

• By end user, the biopharmaceutical and pharmaceutical companies segment held the highest market share in 2024. These organizations are the primary consumers of mRNA synthesis raw materials due to their extensive involvement in drug discovery, therapeutic development, and large-scale vaccine manufacturing, making them key drivers of market demand.

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Market Size & Forecast:

• 2024 Market Size: USD 1.67 Billion

• 2030 Projected Market Size: USD 2.30 Billion

• CAGR (2025-2030): 5.78%

• North America: Largest market in 2024

• Asia Pacific: Fastest growing market

Key Companies & Market Share Insights:

Key players operating in the mRNA synthesis raw materials industry are actively implementing a variety of strategic initiatives to enhance their market presence and broaden the reach of their products and services. These initiatives include expansion activities, such as increasing production capacity, entering new geographic markets, and developing advanced manufacturing facilities to meet growing demand. In addition, partnerships and collaborations with research organizations, pharmaceutical companies, and biotechnology firms play a crucial role in driving market growth by facilitating innovation, improving supply chain efficiency, and enabling the development of new applications for mRNA technologies. By pursuing these strategies, companies aim to strengthen their competitive positioning and capitalize on the increasing adoption of mRNA-based therapeutics and vaccines globally

Key Players

• F. Hoffmann-La Roche Ltd.

• Jena Bioscience GmbH

• Merck KGaA

• Yeasen Biotechnology (Shanghai) Co., Ltd.

• BOC Sciences

• Thermo Fisher Scientific, Inc.

• Maravai LifeSciences

• New England Biolabs

• Creative Biogene

• HONGENE.

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Conclusion:

The mRNA synthesis raw materials market is poised for steady growth, supported by strong academic and industrial interest in mRNA technologies, increasing use in vaccines and therapeutics, and continuous advancement in synthesis methods. Despite cost and regulatory challenges, rising investments, strategic partnerships, and technological innovation are expected to expand the supply of high-quality raw materials to meet future demand.