CASO STRANO? IL VACCINO contro l'HANTAVIRUS È STATO GIÀ DEPOSITATO NEL 2022???

Certamente. Ecco il contenuto del file che hai caricato, letto e poi tradotto in italiano.

TESTO PRESENTE NEL BREVETTO:

Bukreyev et al.

(19) United States
(12) Patent Application Publication
(54) MRNA VACCINES AGAINST HANTAVIRUS

(71) Applicant: Board of Regents, The University of Texas System, Austin, TX (US)

(72) Inventors: Alexander Bukreyev, Galveston, TX (US); Mariano Garcia-Blanco, Galveston, TX (US); Ivan Kuzmin, Galveston, TX (US); Ruben Soto Acosta, Galveston, TX (US)

(21) Appl. No.: 18/691,787
(22) PCT Filed: Sep. 15, 2022
(86) PCT No.: PCT/US2022/043631
§ 371 (e)(1), (2) Date: Mar. 13, 2024

Related U.S. Application Data
(60) Provisional application No. 63/245,101, filed on Sep. 16, 2021.

Publication Classification
(51) Int. Cl.
A61K 39/12 (2006.01)
A61K 39/00 (2006.01)
A61P 31/14 (2006.01)
C12N 7/00 (2006.01)

(52) U.S. Cl.
CPC
A61K 39/12 (2013.01);
A61P 31/14 (2018.01);
C12N 7/00 (2013.01);
A61K 2039/53 (2013.01);
A61K 2039/575 (2013.01);
C12N 2760/12134 (2013.01)

(10) Pub. No.: US 2025/0127870 A1
(43) Pub. Date: Apr. 24, 2025

ABSTRACT

One solution to the problem of Hantavirus pathology is design, production, and administration of a nucleic acid vaccine (NAV). In certain aspects the NAV is an mRNA vaccine. Certain embodiments are directed to the use of a polyprotein, which is cleaved to produce Gn (N-terminal) and Gc (C-terminal) glycoproteins, the Gn glycoprotein, the Gc glycoprotein, or the Gn and Gc glycoproteins of hantaviruses as protective antigen(s) for development of hantavirus vaccines. The Gn/Gc protein, which is cleaved post-translationally to individual Gn and Gc proteins, can be used as an antigen for vaccines. In case of DNA and RNA-based vaccines, the complete M gene, which encodes the complete single open reading frame, which is cleaved post-translationally into the Gn and Gc proteins or individual open reading frames encoding either Gn or Gc, is used.

Specification includes a Sequence Listing.

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Traduzione in italiano

Bukreyev et al.

(19) Stati Uniti
(12) Domanda di brevetto
(54) VACCINI A MRNA CONTRO HANTAVIRUS

(71) Richiedente: Board of Regents, The University of Texas System, Austin, TX (USA)

(72) Inventori: Alexander Bukreyev, Galveston, TX (USA); Mariano Garcia-Blanco, Galveston, TX (USA); Ivan Kuzmin, Galveston, TX (USA); Ruben Soto Acosta, Galveston, TX (USA)

(21) Numero pratica: 18/691,787
(22) Deposito PCT: 15 settembre 2022
(86) Numero PCT: PCT/US2022/043631
Data di ingresso fase nazionale § 371 (e)(1), (2): 13 marzo 2024

Dati di domanda USA correlati
(60) Domanda provvisoria n. 63/245,101, depositata il 16 settembre 2021.

Classificazione di pubblicazione
(51) Classificazione internazionale (Int. Cl.)
A61K 39/12 (2006.01)
A61K 39/00 (2006.01)
A61P 31/14 (2006.01)
C12N 7/00 (2006.01)

(52) Classificazione USA (CPC)
A61K 39/12 (2013.01);
A61P 31/14 (2018.01);
C12N 7/00 (2013.01);
A61K 2039/53 (2013.01);
A61K 2039/575 (2013.01);
C12N 2760/12134 (2013.01)

(10) Numero pubblicazione: US 2025/0127870 A1
(43) Data di pubblicazione: 24 aprile 2025

SOMMARIO

Una soluzione al problema della patologia da Hantavirus è la progettazione, produzione e somministrazione di un vaccino a base di acidi nucleici (NAV). In alcuni aspetti, il NAV è un vaccino a mRNA. Alcuni embodiment (realizzazioni) riguardano l'uso di una poliproteina, che viene scissa per produrre le glicoproteine Gn (N-terminale) e Gc (C-terminale), la glicoproteina Gn, la glicoproteina Gc, o le glicoproteine Gn e Gc degli hantavirus come antigene/i protettivo/i per lo sviluppo di vaccini contro l'hantavirus. La proteina Gn/Gc, che viene scissa post-traduzionalmente nelle singole proteine Gn e Gc, può essere utilizzata come antigene per i vaccini. Nel caso di vaccini basati su DNA e RNA, viene utilizzato il gene M completo, che codifica per l'unico intero open reading frame (quadro di lettura aperto), che viene scisso post-traduzionalmente nelle proteine Gn e Gc, oppure open reading frame individuali che codificano per Gn o Gc.

La descrizione include un elenco di sequenze.

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