The global low temperature sterilization market size was estimated at USD 2.74 billion in 2024 and is projected to reach USD 5.07 billion by 2030, growing at a CAGR of 10.99% from 2025 to 2030. The market growth is primarily driven by the increasing demand for sterilization methods that are safe for heat-sensitive medical instruments and devices, which are widely used in modern healthcare settings.

Healthcare facilities are increasingly adopting low temperature sterilization technologies, such as hydrogen peroxide plasma and ethylene oxide sterilization, as the prevalence of minimally invasive surgeries and the use of advanced medical equipment continue to rise. These sterilization methods are particularly valued because they effectively eliminate pathogens without damaging delicate instruments, ensuring both patient safety and equipment longevity.

Another key factor driving market growth is the rising incidence of healthcare-associated infections (HAIs). Low temperature sterilization methods are critical for sanitizing delicate medical instruments, including thermometers, endoscopes, and other reusable devices, thereby preventing the spread of infections in clinical environments. According to data published by the World Health Organization (WHO) in May 2022, in acute-care settings, approximately 15 out of every 100 patients in low- and middle-income countries, and 7 out of every 100 patients in high-income countries, are likely to acquire at least one HAI during their hospital stay. On average, one in ten patients affected by an HAI may succumb to the infection, highlighting the critical need for stringent infection control measures. This underscores the growing demand for advanced low temperature sterilization technologies as healthcare facilities seek to improve patient safety and reduce infection-related mortality.

Key Market Trends & Insights:

• In 2024, the North American low temperature sterilization market dominated the global landscape, accounting for a share of 34.44%. This regional leadership is attributed to the presence of advanced healthcare infrastructure, widespread adoption of cutting-edge medical technologies, and strong regulatory support for infection control measures. Within North America, the U.S. market held a particularly significant share, driven by the high prevalence of minimally invasive procedures, growing awareness of healthcare-associated infections (HAIs), and strong investments in hospital sterilization technologies.

• By product, the ethylene oxide (EtO) sterilizers segment captured the largest revenue share of approximately 50.01% in 2024. EtO sterilization remains highly preferred due to its ability to effectively sterilize heat- and moisture-sensitive medical instruments, making it suitable for a wide range of delicate healthcare devices while maintaining high efficacy against pathogens.

• By device type, the endoscopes segment held the largest revenue share in 2024. Endoscopes are frequently used in minimally invasive surgeries and diagnostic procedures, and their complex design and delicate components make low temperature sterilization essential to ensure proper disinfection without causing damage. The high utilization of endoscopes in hospitals and clinics, coupled with the need for safe and effective sterilization, continues to drive strong demand for low temperature sterilization solutions in North America.

Order a free sample PDF of the Low Temperature Sterilization Market Intelligence Study, published by Grand View Research.

Market Size & Forecast:

• 2024 Market Size: USD 2.74 Billion

• 2030 Projected Market Size: USD 5.07 Billion

• CAGR (2025-2030): 10.99%

• North America: Largest market in 2024

• Asia Pacific: Fastest growing market

Key Companies & Market Share Insights:

Key players in the low temperature sterilization market are actively focusing on introducing innovative ultrasonic cleaning technologies, implementing growth strategies, and leveraging technological advancements to strengthen their market positions. For example, in March 2024, Getinge announced the complete acquisition of Ultra Clean Systems Inc., a prominent U.S.-based manufacturer of ultrasonic cleaning technologies.

Ultrasonic cleaning technologies are widely utilized in hospitals, surgery centers, and other healthcare facilities for the effective decontamination of surgical instruments and delicate medical devices. These technologies use high-frequency sound waves to remove contaminants, including bacteria, blood, and tissue residues, ensuring that instruments are properly sterilized before use.

The ongoing innovation and adoption of advanced ultrasonic cleaning solutions are expected to significantly enhance the efficiency, safety, and reliability of sterilization processes. Combined with strategic acquisitions, product launches, and technological advancements, these developments are anticipated to drive market growth and expand the adoption of low temperature sterilization solutions over the forecast period.

Key Players

• ASP Global (Fortive Corporation)

• Getinge

• STERIS

• Stryker

• TDK Corporation

• 3M

• Steelco S.p.A.

• Bionics Scientific (a Unit of Kartal Projects Pvt Ltd.)

• DE LAMA S.P.A.

• Genist Technocracy Pvt. Ltd.

• Andersen Sterilizers

• Labotronics Scientific

• Labtron Equipment Ltd

• Qingdao Antech Scientific Co., Ltd.

• Renosem

• Scitek Global Co., Ltd.

• SOLSTEO

• Sterile Safequip And Chemicals Llp

• Tuttnauer

• HUMAN MEDITEK CO., LTD.

• MMM Group

• Canon Singapore Pte. Ltd.

• INSTECH SYSTEMS

• Biobase Biodusty (Shandong), Co., Ltd.

• Telstar (Azbil Group)

• Shinva Medical Instrument Co., Ltd.

Explore Horizon Databook – The world's most expansive market intelligence platform developed by Grand View Research.

Conclusion:

The global low temperature sterilization market is experiencing significant growth, driven by the increasing demand for sterilization methods that are safe for heat-sensitive medical instruments and devices. Healthcare facilities are increasingly adopting low temperature sterilization technologies, such as hydrogen peroxide plasma and ethylene oxide sterilization, to effectively sterilize delicate devices without causing damage. The rising incidence of healthcare-associated infections (HAIs) is further propelling the demand for these sterilization solutions, as they effectively sanitize medical instruments like thermometers and endoscopes. Technological advancements and regulatory approvals, such as the FDA's approval of vaporized hydrogen peroxide for medical device sterilization, are expected to boost market growth in the coming years.